The latest Chrome 22 Developer comes with a very handy new feature - configurable keyboard shortcuts for extensions buttons. What it allows you to do is assign keyboard shortcuts to different buttons added to the toolbar by installed extension. So instead of clicking on a button press the associated keyboard shortcut. This is a great way to get rid of buttons clogging up your toolbar as you can simulate button presses with a shortcut key.
To set up custom keyboard shortcuts open Settings > Tool > Extensions. Scroll down to the bottom of the page and select Configure Commands. A popup box will display the extensions that support this feature. You can then enter a keyboard combination in the box against each extension.
The usefulness of the shortcut will depend entirely on the extensions. For example, they're useful for the "Google +1 Button" extension because you can quickly +1 pages, but they're not useful for the LastPass extension because it only displays a long list of options.
There's an experimental Chrome API for extension developers that allows them to add keyboard shortcuts that trigger actions.
Some shortcuts that work: Ctrl+Letter, Ctrl+Digit, Ctrl+Shift+Letter, Ctrl+Shift+Digit.
[via Google Operating System]