Locate32 is a search tool for Windows that can perform searches at the blink of an eye. This is possible because unlike Windows' default search application, Locate32 does not search the hard drive in real time. Instead, it first scans your hard drive and builds a databases to store information about the files on your hard drives and the directory structures, and then uses these databases to perform searches. Actually, this technique of indexing and using the index to search is used by all desktop search applications like Google Desktop Search and Copernicus Search, with one exception. Other search applications run continually in the background to index files. Locate32 on the other hand, has a scheduler to update the database and runs only at specific time. The updating is fast and takes just a couple of minutes for indexing a few tens of gigabytes of stuff.
Locate32 is ten times better than the Windows search. If you use the search features, which I guess you do, I don't see any reason why you should use the default Windows tool.